【直播回顾】新视界跨学科名医论坛第二期

昨日（12月02日）晚上，新视界跨学科名医论坛第二期直播圆满结束。4位中山大学中山眼科中心不同学科专家，眼外伤科林晓峰教授担任主持嘉宾，眼整形科黄丹平教授、眼底外科胡洁教授、眼外伤科＆急症科娄秉盛教授，就“硅油依赖眼的出路在哪里？”进行深度访谈，为大家提供了一场精彩的学术盛宴。四位专家针对什么是硅油依赖眼，硅油依赖眼的形成原因及治疗方式，尤其是创新治疗植入折叠式人工玻璃体球囊治疗进行讲解。在直播间许有多人在线上提问，各位教授也一一进行解答，直播间异常火爆。
可直接扫码进入直播间观看回放

此次直播共有2个平台同步直播，观看数据如下：
01格度医云
最高同时在线1963人并发观看；会议期间累计观看人数约为：3547人，覆盖地区逾30个。
02医师服务
观看人数：329人，观看次数414次，覆盖多个地区。
此前在10月21日，开展了第一期直播探讨“角膜损伤后散光的产生及处理”，共有三千多人观看，获得了广泛关注，进入直播间也可观看第一期视频回顾。第三期名医论坛将在2022年1月6日举行，敬请期待！ 

栏目简介●●●
 名医论坛
搭建跨越不同学科的学术平台，邀请各学科领域专家学者，每期以各学科热点难点话题，探讨疑难病例、创新产品与技术，进行多元化交流，展现学术风采。
  特色板块 
名医面对面>>各界名医无缝交流，高峰论坛碰撞思想火花跨学科产品速递>>名医深度解析不同学科创新产品和技术

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【直播回顾】新视界跨学科名医论坛第三期

1月25日晚上，新视界跨学科名医论坛第三期直播圆满结束！中山大学中山眼科中心不同学科的四位专家，眼底外科胡洁教授担任主持嘉宾联袂白内障科罗莉霞教授、小儿眼病&眼底外科丁小燕教授和眼外伤科何丽文教授，放眼眼科历史之河，回眸过往，共同对眼科重大发明发现进行多维度深度讨论与解析。

四位教授齐聚一堂，分别从古代萌芽、16世纪至18世纪奠基、近代19世纪独立发展、 20世纪飞速发展和现代中国眼科发展时期分享了眼底外科、白内障科和眼外伤科中里程碑式的人物故事和发明技术。四位专家深入浅出、风趣幽默，带领我们徜徉眼科历史长河，欣赏一颗颗熠熠生辉的“明珠”。如：近代眼视光学的奠基者开普勒（ Kepler ）、眼生理学之父托马斯·扬(Thomas Young ) 、超乳的发明者Charles D. Kelman、视网膜脱离之父Jules Gonin等等，欲知更多，欢迎扫码观看~▽▽


△识别二维码进观看视频

此次直播共有2个平台同步直播，观看数据如下：

01 格度医云公众号

最高同时在线1040人并发观看；会议期间累计观看人数约为2173人，覆盖地区逾15个。

02 医师服务AP

观看人数582人，观看人次1326人。

此前在2021年，名医论坛共开展两期直播，分别为“角膜损伤后散光的产生及处理”和“硅油依赖眼的出路在哪里？”，共有五千多人观看实时直播。未来，卫视博还将以北京、上海为直播基地，邀请全国各地专家名医进行直播分享，敬请期待！

名医论坛

搭建跨越不同学科的学术平台，邀请各学科领域专家学者，每期以各学科热点难点话题，探讨疑难病例、创新产品与技术，进行多元化交流，展现学术风采。

特色板块:

名医面对面>>各界名医无缝交流，高峰论坛碰撞思想火花

跨学科产品速递>>名医深度解析不同学科创新产品和技术

 

名医论坛系列仍在进行人气话题火热征集中，您想了解什么学科什么话题？热点资讯？疑难病例？创新技术？

欢迎留言或发送想了解的学术话题，进行话题提名，我们将选取大家关注的人气话题，特邀该领域专家名医为您解答！

长按下方二维码可直接进入直播间

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年终盘点 | 卫视博2021大事件，感谢您的一路同行！

2021年波折迭起，虽仍有疫情和灾难交织，但感动与收获同在。让我们回顾年终总结，

积攒温暖，与光同行！

01
专精特新企业
入库广州市专精特新企业
02
国内FCVB临床应用新进展
2021年，复旦大学附属眼耳鼻喉科医院等多家医院成功开展首例FCVB手术，至今已有两百多家医院引进FCVB新技术，为广大眼外伤和硅油依赖眼患者保住眼球。
03
FCVB新技术病例研讨会
卫视博陆续在全国各地开展新技术讨论会，覆盖多个地区。此外，举办了重症眼外伤处理暨折叠式人工玻璃体球囊进展学习班，探讨重症眼外伤处理和FCVB新技术。
04
FCVB参展＆卫星会
卫视博参展Retina China 2021，举办卫星会。国家眼部疾病临床医学研究中心主任、中华医学会眼科学分会眼底病学组组长许迅教授，空军军医大学西京医院惠延年教授和北京同仁医院魏文斌教授作为卫星会主席，北京同仁医院王绍莉教授、复旦大学附属眼耳鼻喉科医院江睿教授、哈尔滨医科大学附属第二医院孙大卫教授分享FCVB病例。
05
FCVB入选三级公立医院绩效考核四级手术目录（2019版）
序号：341手术操作编码：14.7203手术操作描述：后入路玻璃体切割术伴人工玻璃体置入术
06
电视台报道新技术
中央广播电视总台综合频道（CCTV-1）报道创新医疗新技术《人工玻璃体球囊 保住萎缩的眼球》，由首都医科大学附属北京同仁医院史翔宇教授结合动画讲解“折叠式人工玻璃体球囊”是如何保住眼球萎缩的眼睛。
广东经济频道《广东新焦点》栏目报道广州卫视博公司科技创新促发展，首创折叠式人工玻璃体球囊技术保眼球。
07
FCB多中心临床研究新进展
多家医院同步开展FCB多中心临床研究，取得新进展。
08
高度近视后巩膜加固系统
首都医科大学附属北京同仁医院、首都医科大学附属北京友谊医院、温州医科大学附属眼视光医院、广州中医药大学第一附属医院已正式开展高度近视后巩膜加固系统探索性临床试验，取得突破性进展。
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9月 | Vesber 最佳RIO论文推荐

卫视博每月从三大权威杂志：Retina、Investigative Ophthalmology & Visual Science、Ophthalmology中各推荐一篇眼科论文。— — 最佳“RIO”论文推荐（9月）Evaluation of the efficacy of posterior scleral contraction in the treatment of macular hole with retinal detachment in high myopia Macular surgery on sclera(Ye J, Wu Y, Zhu S, et al. EVALUATION OF THE EFFICACY OF POSTERIOR SCLERAL CONTRACTION IN THE TREATMENT OF MACULAR HOLE WITH RETINAL DETACHMENT IN HIGH MYOPIA. Retina. 2021;41(9)_1874-1882.）
后巩膜收缩术治疗高度近视黄斑裂孔合并视网膜脱离的手术疗效评价
Purpose
To evaluate efficacy of posterior scleral contraction (PSC) for macular hole withretinal detachment (MHRD) in high myopia.评价后巩膜收缩术（PSC）治疗高度近视黄斑裂孔合并视网膜脱离（MHRD）的疗效。
Methods
Seventy-three MHRD eyes were treated with PSC. A strip was sent across inferiortemporal scleral surface to posterior pole, then two ends were led out from nasal-inferior and temporal-superior areas. It was tightened to contract posterior sclera with designed axial length (AL) shortening ([10% of pre-operative AL-0.5]mm) after aqueous humors drained from anterior chamber. Recovery was classified as type I (retinal reattachment with MH bridged) and II (retinal reattachment without MH bridged). Follow-up duration was 25.3±18.0 months.73只高度近视黄斑裂孔合并视网膜脱离眼接受后巩膜收缩术治疗。将条带穿过颞下巩膜面至后极，然后从鼻下区和颞上区引出两端。前房排出房水后，用设计的轴向长度（AL）缩短法（[10%术前轴向长度-0.5]mm）收紧后巩膜，以收缩后巩膜。恢复类别分为I型（黄斑裂孔桥接的视网膜复位）和II型（无黄斑裂孔桥接的视网膜复位）。随访时间为25.3±18.0个月。
Results
AL was 30.01±2.27mm at pre-operation and shortened by 2.57±0.82mm intraoperatively. At final post-operation, maintained AL shortening was 1.87±0.92mm. Forty-six eyes (63.0%) recovered as type I and 26 eyes (35.6%) as type II, 1 eye (1.4%) unrecovered. Postoperative best-corrected visual acuity (BCVA, logarithm of minimal angle of resolution [LogMAR]) was better than pre-operative one (0.85±0.50 [Snellen 20/125] vs. 1.11±0.56 [Snellen 20/250], P<0.001) with correlation (r=0.662, P<0.001) and consistency (Kappa=0.34, P<0.001) between two. BCVA improvement didn’t differ between recovery types (P=0.206).术前轴向长度为30.01±2.27mm，术中缩短2.57±0.82mm。术后最后一次手术时，维持的轴向长度缩短为1.87±0.92mm。46只眼（63.0%）恢复为I型，26只眼（35.6%）恢复为II型，1只眼（1.4%）未恢复。术后最佳矫正视力（BCVA，最小分辨角对数[LogMAR]）优于术前（0.85±0.50[Snellen 20/125]vs.1.11±0.56[Snellen 20/250]，P<0.001），两者之间具有相关性（r=0.662，P<0.001）和一致性（Kappa=0.34，P<0.001）。恢复类型之间的术后最佳矫正视力改善没有差异（P=0.206）。
Conclusion
MHRD was successfully recovered by PSC with AL shortening. Visual improvement was achieved, correlated and consistent with pre-operative BCVA while independent of recovery types.黄斑裂孔伴视网膜脱离通过后巩膜收缩和轴向长度缩短成功恢复。视力得到改善，与术前最佳矫正视力一致，且与恢复类型无关。
推荐理由
本文研究了高度近视黄斑裂孔伴视网膜脱离患者采用巩膜加压术进行治疗，术后视网膜复位，眼轴缩短，手术治疗效果好。本文创新之处在于对比了术后不同类型的恢复与最佳矫正视力之间的关系，得出恢复类型与视力之间不具相关性。
文章不足之处在于文章病例随访时间显示，手术末次随访的眼轴数据较术中缩短的数据缩短的区间有所降低，对于更远期的随访，比如5年、10年是否依旧能够维持是个未知数，需进一步随访观察。
No.2
Investigative Ophthalmology & Visual Science · 推荐
COVID-19 Home Quarantine Accelerated the Progression of Myopia in Children Aged 7 to 12 Years in China( Ma M, Xiong S, Zhao S, Zheng Z, Sun T, Li C. COVID-19 Home Quarantine Accelerated the Progression of Myopia in Children Aged 7 to 12 Years in China. Invest Ophthalmol Vis Sci. 2021;62(10)_37.）
新冠病毒-19家庭隔离加速了中国7-12岁儿童近视的发展
Purpose
To investigate the effect of home quarantine during the COVID-19 pandemic on myopia progression in children and its associated factors.探讨在COVID-19大流行期间，家庭隔离对儿童近视进展的影响及其相关因素。
Methods
Myopic children aged 7 to 12 years with regular follow-up visits every half a year from April 2019 to May 2020 were included. Cycloplegic refraction was measured at baseline and at two follow-up visits. The first follow-up visit (visit 1) was conducted before the COVID-19 home quarantine, whereas the second (visit 2) was four months after the home quarantine. Myopia progression at visits 1 and 2 were compared. Factors associated with changes in myopia progression were tested with a multiple regression analysis.包括2019年4月至2020年5月每半年定期随访的7至12岁近视儿童。在基线检查和两次随访时测量睫状肌麻痹性屈光。第一次随访（第1次随访）是在COVID-19家庭隔离之前进行的，而第二次随访（第2次随访）是在家庭隔离四个月之后进行的。比较第1次和第2次就诊时的近视进展情况。用多元回归分析测试与近视进展变化相关的因素。
Results
In total, 201 myopic children were enrolled. There was a significantly greater change in spherical equivalent at visit 2 (−0.98 ± 0.52 D) than at visit 1 (−0.39 ± 0.58 D; P < 0.001). Students were reported to have spent more time on digital devices for online learning (P < 0.001) and less time on outdoor activities (P < 0.001) at visit 2 than at visit 1. Children using television and projectors had significantly less myopic shift than those using tablets and mobile phones (P < 0.001). More time spent on digital screens (β = 0.211, P < 0.001), but not less time on outdoor activities (β = −0.106, P = 0.110), was associated with greater myopia progression at visit 2.总共有201名近视儿童入选。在第2次就诊时(−0.98±0.52 D），比第1次随访时(−0.39±0.58天；P<0.001）球面当量的变化显著更大。据报道，与第1次随访相比，第2次随访的学生在用于在线学习的数字设备上花费的时间更多（P<0.001），而在户外活动上花费的时间更少（P<0.001）。与使用平板电脑和手机的儿童相比，使用电视和投影仪的儿童近视转移明显减少（P<0.001）。在第2次随访时发现，控制户外活动的时间不降低（β=−0.106，P=0.110），但是在数字屏幕上花费的时间增加（β=0.211，P<0.001），近视进展同样显著。
Conclusion
Changes in behavior and myopic progression were found during the COVID-19 home quarantine. Myopic progression was associated with digital screen use for online learning, but not time spent on outdoor activities. The projector and television could be better choices for online learning.在COVID-19居家隔离期间发现了行为和近视进展的变化。近视进展与在线学习使用数字屏幕有关，但与户外活动时间无关。投影仪和电视可能是在线学习的更好选择。
推荐理由
本文研究了新冠疫情期间，居家隔离的防控政策对教学方式的改变进一步影响了儿童近视的发展，得出数字屏幕的使用时间与近视的发展想关。文章创新之处在于通过借助社会环境改变的背景设置变量，收集到数字屏幕的使用时长与近视关联，得出针对该环境下更有利于控制近视防控的建议。本文的不足之处在于仅分析了儿童屈光度的进展改变，未收集其他数据改变，例如视力，未来可进一步丰富研究内容。
No.3
Ophthalmology · 推荐
Bidirectional Association between Visual Impairment and Dementia Among Older Adults in the United States Over Time(Chen SP, Azad AD, Pershing S. Bidirectional Association between Visual Impairment and Dementia Among Older Adults in the United States Over Time. Ophthalmology. 2021;128(9)_1276-1283.）
随着时间的推移，美国老年人视力障碍和痴呆症之间的相互影响
Purpose
Although visual impairment (VI) has been associated with worse cognitive performance among older adults, the temporal relationship between the 2 remains subject to debate. Our objective was to investigate the longitudinal impact of VI on cognitive function and vice versa.尽管视力障碍（VI）与老年人的认知能力较差（老年痴呆症）有关，但两者之间的先后影响关系仍存在争议。我们的目的是研究视力障碍与老年痴呆症的相互影响关系。
Design
Retrospective, time-to-event study.回顾性、事件时间研究。
Participants
National Health and Aging Trends Study (NHATS) participants from 2011 to 2018 cycles.参与者为入选2011年至2018年国家健康和老龄化趋势研究（NHAT）的人员。
Methods
A total of 10 676 participants aged 65 years and older were included. Cox proportional hazards regression models evaluated the impact of baseline VI on subsequent dementia and impact of baseline dementia on subsequent VI. Models were adjusted for potential confounding variables, including demographics, clinical comorbidities, and hearing and physical function limitations.共有10676名65岁及以上的参与者被纳入研究。采用考克斯比例风险回归模型，评估初始视力障碍人群继发痴呆的概率以及初始痴呆患者后续继发视力障碍的概率。模型针对潜在的混杂变量进行干扰排除，包括人口统计学、临床共病、听力和身体功能限制。
Main Outcome Measures
Hazard ratio (HR) for incident dementia among participants with baseline selfreported VI and HR for incident VI among participants with baseline dementia.初始视力损害参与者中继发痴呆的比例和初始痴呆参与者中继发视力损害的比例。
Results
Of the 10 676 participants included in the analysis, approximately 40% were aged 65-74 years, 40% were aged 75-84 years, and the remaining 20% were aged 85 years and older. The majority were female (59%), and 68% self-identifified as non-Hispanic White. Among participants with normal cognitive status at baseline, subsequent dementia was observed in 1753 (16%), and among participants with normal self-reported vision at baseline, subsequent VI was reported in 2371 (22%). In adjusted regression models, participants with baseline VI had higher likelihood of developing dementia over subsequent follow-up (HR, 2.3; 95% confifidence interval [CI], 2.0e2.6; P < 0.001). Likewise, participants with baseline dementia had a higher likelihood of developing self-reported VI over time (HR, 2.5; 95% CI, 2.2e2.8; P < 0.001).在纳入分析的10676名参与者中，约40%的人年龄在65-74岁，40%的人年龄在75-84岁，其余20%的人年龄在85岁及以上。大多数是女性（59%），68%的非西班牙裔白人。在初始检查时非老年痴呆症的参与者中，1753人（16%）出现继发性痴呆，在初始检查时视力正常的参与者中，2371人（22%）出现继发性视力障碍。在调整后的回归模型中，初始为视力障碍的参与者在随后的随访中发生痴呆的可能性更高（HR，2.3；95%可信区间[CI]，2.0-2.6；P<0.001）。同样，初始痴呆患者随着时间的推移出现视力障碍的可能性也更高（HR，2.5；95%CI，2.2-2.8；P<0.001）。
Conclusion
Self-reported VI in the US Medicare population is associated with greater dementia likelihood over time, and dementia is similarly associated with greater VI likelihood over time. Associations are likely multifactorial and bidirectional and could be explained by intervening variables in the path from VI to dementia, or vice versa, or by common risk factors for pathological processes in both eyes and brain. These fifindings suggest the need for early identifification of older adults with visual compromise and consideration of visual disability in the cognitively impaired.美国医疗保险人群中视力障碍患者继发老年痴呆有更大的可能性，而痴呆症随着时间的推移继发视力障碍也有更大的可能性。该影响可能是多因素和双向的，可以通过从视力障碍与痴呆的途径中的干预变量来解释，或者通过眼睛和大脑病理过程的共同风险因素来解释。这些发现表明，有必要早期识别患有视力损害的老年人，并重视痴呆患者的视力障碍。
推荐理由
本研究探索了美国老年人视力障碍和痴呆症之间的双向关联,得出两者之间的关系是双向的，相互影响。文章创新点是通过数万人的大样本统计数据进行概率分析，发现视力障碍的参与者继发痴呆的可能性比非视力障碍者更高。痴呆患者继发视力障碍的可能性比非痴呆参与者更高。文章的不足之处为变量因素复杂，尽管在统计学中排除了无关变量，但是对于一些多因素综合影响的结果，无关变量并不是绝对的无关因素，未来须从多个角度，多个方向继续探讨。
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10月 | Vesber 最佳RIO论文推荐

卫视博每月从三大权威杂志：Retina、Investigative Ophthalmology & Visual Science、Ophthalmology中各推荐一篇眼科论文。— — 最佳“RIO”论文推荐（10月）

No.1
Retina · 推荐
FULL-THICKNESS MACULAR HOLE IN AGE-RELATED MACULAR DEGENERATION PATIENTS WITH TWO DISTINCT ENTITIES(Retina. 2021;41(10):2066-2072.）

年龄相关性黄斑变性患者的全厚度黄斑裂孔，有两种不同的表现
Purpose
To describe optical coherence tomography characteristics of full-thickness macular holes (FTMHs) in age-related macular degeneration patients.描述年龄相关性黄斑变性患者全厚度黄斑裂孔（FTMHs）的光学相干断层扫描特征。

Methods
A multicenter, retrospective, observational case series of patients diagnosed with age-related macular degeneration and FTMHs seen between January 1, 2009, and January 3, 2020. Clinical charts and spectral-domain optical coherence tomography images were reviewed. Optical coherence tomography findings included FTMH-inverted trapezoid or hourglass appearance, central macular thickness (CMT), complete retinal pigment epithelium and complete retinal outer retinal atrophy, and presence of pigment epithelium detachment and epiretinal membrane. The mean outcome was the morphologic and functional characterization of different subtypes of FTMHs.2009年1月1日至2020年1月3日期间诊断为年龄相关性黄斑变性和FTMHs患者的多中心、回顾性、观察性病例系列。回顾了临床图表和光谱域光学相干断层扫描图像。光学相干断层扫描结果包括FTMH倒梯形或沙漏状外观、中央黄斑厚度（CMT）、完整的视网膜色素上皮和完整的视网膜外萎缩、色素上皮脱离和视网膜前膜。平均结果是不同亚型FTMHs的形态和功能特征

Results
A total of 86 eyes of 85 consecutive patients, with mean age of 80.31 ± 8.06 and mean best-corrected visual acuity of 1.17 ± 0.58 logarithm of the minimal angle of resolution. Two different subtypes of FTMHs were identified: tractional and degenerative. Fifty (58%) degenerative FTMHs characterized with inverted trapezoid appearance and 36 (42%) tractional FTMHs characterized with hourglass appearance. Degenerative FTMHs presented with 66% of CMT < 240µm, 14% of CMT > 320, and 70% of complete retinal outer retinal atrophy, in comparison with 41% of CMT < 240µm, 42.9% of CMT > 320%, and 20% of complete retinal outer retinal atrophy in the tractional FTMH group (P= 0.002, 0.003, <0.001, respectively). The presence of epiretinal membrane and pigment epithelium detachment where significantly higher in tractional FTMHs (P= 0.02, 0.03, respectively).85名连续患者共86只眼，平均年龄为80.31±8.06岁，平均最佳矫正视力为最小分辨角对数的1.17±0.58。确定了两种不同的FTMHs亚型：牵引型和退行性。50例（58%）退行性FTMHs表现为倒梯形，36例（42%）牵引性FTMHs表现为沙漏状。与牵引性FTMH组中41%的CMT<240µm、42.9%的CMT>320%和20%的完全性视网膜外萎缩相比，退行性FTMH表现为66%的CMT<240µm、14%的CMT>320和70%的完全性视网膜外萎缩（分别P=0.002、0.003和<0.001）。在牵引性FTMHs中，视网膜前膜和色素上皮脱离的出现率明显较高（分别为P=0.02和0.03）。

Conclusion
Degenerative and tractional FTMHs may be two distinct clinical entities. Discerning degenerative from tractional FTMHs is possible by using optical coherence tomography features including shape of the FTMHs, CMT, internal–external ratio of FTMHs, and presence of complete retinal outer retinal atrophy, pigment epithelium detachment, and epiretinal membrane.Full-thickness macular holes in age-related macular degeneration patients can be divided into tractional and degenerative subgroups. Discerning degenerative from tractional full-thickness macular holes is possible by using optical coherence tomography features including shape of the full-thickness macular holes, central macular thickness, presence of complete retinal outer retinal atrophy, pigment epithelium detachment, and epiretinal membrane.

退行性和牵引性FTMHs可能是两种不同的临床实体。通过光学相干断层扫描特征，包括FTMHs的形状、CMT、FTMHs的内外比、完全性视网膜外萎缩、色素上皮脱离和视网膜前膜，可以区分牵引性FTMHs和退行性FTMHs。

年龄相关性黄斑变性患者的全厚度黄斑裂孔可分为牵引性和变性亚组。通过光学相干断层扫描特征，包括全厚度黄斑裂孔的形状、中央黄斑厚度、是否存在完全的视网膜外萎缩、色素上皮脱离和视网膜前膜，可以区分牵引性全厚度黄斑裂孔和退行性全厚度黄斑裂孔。

推荐理由
该研究帮助临床医生区分了牵引性FTMHs和退行性FTMHs的两种不同表现，文章的创新之处在于通过一年时间的回顾分析86只眼的FTMHs的形状、中央黄斑厚度、是否存在完全的视网膜外萎缩、色素上皮脱离和视网膜前膜的光学相干断层扫描结果，确定了两种不同的FTMH亚型，分别为牵引型和退行性。

文章的不足之处在于虽然描述并比较了牵引性和退行性FTMHs的特征，但没有对接受PPV的患者进行随访，包括视力变化和手术结果。为了更好地了解牵引性和退行性FTMHs的病理生理学和阶段，还需要进行更大规模的前瞻性研究。

No.2
Investigative Ophthalmology & Visual Science · 推荐
Impacts of Systemic Hypertension on the Macular Microvasculature in Diabetic Patients Without Clinical Diabetic Retinopathy( Invest Ophthalmol Vis Sci. 2021;62(12):21.）

全身性高血压对无临床糖尿病视网膜病变的糖尿病患者黄斑微血管的影响
Purpose
Purpose: To identify the impact of hypertension (HTN) on macular microvasculature in type 2 diabetes (T2DM) patients without clinical diabetic retinopathy.探讨高血压（HTN）对无临床糖尿病视网膜病变的2型糖尿病（T2DM）患者黄斑微血管的影响。

Methods
 In this retrospective cross-sectional study, subjects were divided into three groups: controls (control group), patients with T2DM (DM group), and patients with both T2DM and HTN (DM + HTN group). The vessel length density (VD) was compared among the groups. Linear regression analyses were performed to identify factors associated with VD.在这项回顾性横断面研究中，受试者分为三组：对照组（对照组）、2型糖尿病患者（糖尿病组）和2型糖尿病合并HTN患者（糖尿病+HTN组）。比较各组间血管长度密度（VD）。进行线性回归分析以确定与VD相关的因素。

Results
 The VD in the control, DM, and DM + HTN groups was 20.43 ± 1.16, 19.50 ± 1.45, and 18.19 ± 2.06 mm−1, respectively (P < 0.001). The best-corrected visual acuity (B = −9.30; P = 0.002), duration of T2DM (B = −0.04; P = 0.020), HTN (B = −0.51; P = 0.016), signal strength (B = 1.12; P < 0.001), and ganglion cell–inner plexiform layer thickness (B = 0.06; P < 0.001) were significant factors affecting VD in patients with T2DM. Additionally, the hemoglobin A1c (HbA1c) (B = −0.49; P = 0.016) was significantly associated with VD in patients with both T2DM and HTN.对照组、DM组和DM+HTN组的VD分别为20.43±1.16、19.50±1.45和18.19±2.06mm−分别为1例（P<0.001）。最佳矫正视力（B=−9.30；P=0.002），T2DM持续时间（B=−0.04；P=0.020），HTN（B=−0.51；P=0.016）、信号强度（B=1.12；P<0.001）和神经节细胞-内丛状层厚度（B=0.06；P<0.001）是影响T2DM患者VD的重要因素。此外，血红蛋白A1c（HbA1c）（B=−0.49；P=0.016）与T2DM和HTN患者的VD显著相关。

Conclusion
Patients with T2DM had impaired macular microvasculature, and patients with T2DM with HTN exhibited greater impairment of the microvasculature than did patients with T2DM only. Additionally, physicians should be aware that the macular microvasculature would be more vulnerable to hyperglycemic damage under ischemic conditions by HTN.T2DM患者的黄斑微血管受损，T2DM合并HTN患者的微血管受损程度高于单纯T2DM患者。此外，医生应意识到，在HTN引起的缺血条件下，黄斑微血管更容易受到高血糖损伤。

推荐理由
本研究将受试者分为三组进行对照研究，研究结果表明，与健康个体相比，T2DM患者的黄斑微血管系统受损，并且T2DM合并HTN患者表现出比单纯的T2DM患者更严重的微血管损伤。本文的创新之处在于使用了信号强度相对较高的OCTA图像，可以进行准确的分析。此外，很少有研究报告HTN对T2DM患者黄斑微血管系统的影响。

不足之处在于没有确定受损的黄斑微血管系统与视觉功能的各个方面之间的关系，并且无法排除研究患者之前曾发生过HTN视网膜病变但随后消退，这点可能会影响黄斑微血管系统数据。

No.3
Ophthalmology · 推荐
Panretinal Photocoagulation for Diabetic Retinopathy in the RIDE and RISE Trials: Not “1 and Done”(Ophthalmology. 2021;128(10):1448-1457.）

RIDE and RISE试验中糖尿病视网膜病变的全视网膜光凝治疗：不是“1且完成”
Purpose
To evaluate panretinal photocoagulation (PRP) treatment and re-treatment patterns in patients with diabetic retinopathy (DR) and diabetic macular edema (DME).评估糖尿病视网膜病变（DR）和糖尿病黄斑水肿（DME）患者的全视网膜光凝（PRP）治疗和再治疗模式。

Design
Post hoc analysis of the phase 3 RIDE (clinicaltrials.gov identifier,NCT00473382) and RISE (clinicaltrials.gov identifier,NCT00473330) clinical trials of ranibizumab for the treatment of DME.雷尼珠单抗治疗二甲醚的3期临床试验（clinicaltrials.gov标识符，NCT00473382）和RISE（clinicaltrials.gov标识符，NCT00473330）的事后分析。

Participants
Seven hundred fifty-nine patients were randomized for treatment.参与者：759名患者随机接受治疗。

Methods
Panretinal photocoagulation treatment patterns and clinical experiences were assessed by baseline PRP treatment status.通过基线PRP治疗状态评估全视网膜光凝治疗模式和临床经验。

Main Outcome Measures
Number and timing of on-study PRP treatment sessions undergone through month 24. Time to new proliferative event (composite end point) was also assessed.第24个月期间进行的研究中PRP治疗的次数和时间安排。还评估了发生新的增殖事件（复合终点）的时间。

Results
At baseline, approximately 25% of patients in RIDE and RISE had undergone PRP treatment before enrollment (22.2%, 24.4%, and 25.4% of patients in the sham, ranibizumab 0.3 mg, and ranibizumab 0.5 mg arms, respectively). In patients without prior PRP at baseline (n = 577), 9.5% of sham-treated patients underwent 1 or more PRP treatments through month 24, compared with 1.1% and 1.6% of patients receiving ranibizumab 0.3 mg and ranibizumab 0.5 mg, respectively (P < 0.001 for both ranibizumab arms vs. sham). In patients with prior PRP at baseline (n = 182), 19.3% of sham-treated patients underwent 1 or more PRP treatments through month 24. No ranibizumab-treated patients with prior PRP at baseline required additional on-study PRP through month 24 (P < 0.001 for both ranibizumab arms vs. sham). Ranibizumab treatment also significantly reduced clinical DR progression among patients who underwent prior PRP. By month 24 in patients with prior PRP at baseline, the probability of experiencing a new proliferative event was 10.3% and 9.9% in patients receiving ranibizumab 0.3 mg and ranibizumab 0.5 mg treatment, respectively, compared with 39.4% in sham-treated patients (P < 0.0001). Overall, sham-treated patients, including those patients who were PRP naïve at baseline who went on to require PRP, experienced more clinical events than ranibizumab-treated patients.在基线检查时，约25%的RIDE和RISE患者在入组前接受过PRP治疗（假手术组、0.3 mg雷尼珠单抗组和0.5 mg雷尼珠单抗组分别为22.2%、24.4%和25.4%）。在基线检查时无PRP的患者中（n=577），9.5%的假手术治疗患者在24个月内接受了1次或多次PRP治疗，而接受0.3 mg雷尼珠单抗和0.5 mg雷尼珠单抗治疗的患者分别为1.1%和1.6%（雷尼珠单抗组和假手术组的P<0.001）。在基线检查时有PRP病史的患者中（n=182），19.3%的假手术患者在24个月内接受了1次或更多的PRP治疗。在基线检查时有PRP病史的患者，在研究第24个月期间，无需接受雷尼珠单抗治疗的患者需要额外的PRP研究（雷尼珠单抗组和假手术组的P<0.001）。雷尼珠单抗治疗也显著降低了既往PRP患者的临床DR进展。在基线检查时有PRP病史的患者中，到第24个月时，接受0.3 mg雷尼珠单抗和0.5 mg雷尼珠单抗治疗的患者发生新的增殖事件的概率分别为10.3%和9.9%，而接受假治疗的患者发生新的增殖事件的概率为39.4%（P<0.0001）。总的来说，假手术治疗的患者，包括那些在基线检查时PRP幼稚并继续需要PRP的患者，比雷尼单抗治疗的患者经历更多的临床事件。

Conclusion
In RIDE and RISE, PRP treatment was not a “1 and done” procedure, with on-study PRP re-treatment occurring in patients both with and without prior PRP treatment at baseline. Ranibizumab treatment reduced on-study PRP treatment and DR progression regardless of prior PRP treatment status at baseline.在RIDE and RISE中，PRP治疗不是一个“一劳永逸”的过程，在基线检查时，既往接受过PRP治疗的患者和未接受过PRP治疗的患者都会进行研究中的PRP再治疗。无论基线检查时PRP治疗前的状态如何，研究中PRP治疗和DR进展的雷尼珠单抗治疗均减少。

推荐理由
本研究分为3个治疗组（假手术组、雷珠单抗0.3毫克、雷珠单抗0.5毫克），根据基线PRP状态进行分析。在治疗组之间比较PRP治疗事件的数量和时间，为了更好地理解既往PRP治疗与DR恶化之间的关系，使用先前描述的新增殖事件的复合终点时间对既往PRP患者进行DR恶化评估。发现雷珠单抗治疗延迟了发生新增殖事件的时间。 本研究的创新之处在于本研究结果挑战了PRP是一次性手术的看法，与PRP相比，抗VEGF治疗可改善视力、解剖和DR严重程度。并建议临床中在评估PDR患者时，可考虑将雷珠单抗治疗作为独立的选择或与PRP一起使用。 本研究不足之处是在雷珠单抗组中接受研究中PRP的患者数量很少，这限制了组间比较。
三篇论文原文已放在百度网盘中，点击下方“阅读原文”，输入提取码：fcvb ，即可下载原文。
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新视界跨学科名医论坛第一期直播圆满举行

10月21日晚上，新视界跨学科名医论坛第一期直播圆满结束。4位中山大学中山眼科中心不同学科专家，眼外伤科林晓峰教授担任主持嘉宾，白内障科郑丹莹教授、屈光与低视力科杨晓教授、角膜科梁凌毅教授，就“角膜损伤后散光的产生及处理”进行深度访谈，探讨不规则散光的类型、早期干预办法、后期解决方案，以及针对散光的创新治疗等内容，为大家提供了一场精彩的学术盛宴！值得一提的是，在直播中有多人陆续进行线上提问，各位教授也一一进行解答。

此次直播共有2个平台同步直播，线上共计3226人观看。

01格度医云

最高同时在线1468人并发观看；会议期间累计观看人数约为：2739人，覆盖地区逾18个。

02医事公开课

观看人数：487人。

也可扫码进入直播间观看回放

栏目简介●●●

 名医论坛

搭建跨越不同学科的学术平台，邀请各学科领域专家学者，每期以各学科热点难点话题，探讨疑难病例、创新产品与技术，进行多元化交流，展现学术风采。

  特色板块 

名医面对面>>各界名医无缝交流，高峰论坛碰撞思想火花

跨学科产品速递>>名医深度解析不同学科创新产品和技术

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8月 | Vesber 最佳RIO论文推荐

卫视博每月从三大权威杂志：Retina、Investigative Ophthalmology & Visual Science、Ophthalmology中各推荐一篇眼科论文。

— — 最佳“RIO”论文推荐（8月）

No.1     Retina · 推荐
RETINAL SURFACE WRINKLING AS AN INDICATOR FOR INTERNAL LIMITING MEMBRANE PEELING DURING VITRECTOMY FOR RETINAL DETACHMENT(Retina: August 2021 – Volume 41 – Issue 8 – p 1618-1626）

视网膜表面起皱作为指示剂的内界膜剥离时玻璃体切除视网膜脱离
Purpose：To assess the validity of retinal surface wrinkling (RSW) as an indicator to select patients relevant for internal limiting membrane peeling during vitrectomy for rhegmatogenous retinal detachment, to prevent postoperative visual decline due to epiretinal membrane growth.
评估视网膜表面皱褶（RSW）作为一项指标的有效性，以选择与孔源性视网膜脱离玻璃体切除术中内界膜剥离相关的患者，防止因视网膜前膜生长导致术后视力下降。
Methods：This was a prospective, interventional case series of 78 consecutive eyes that underwent initial vitrectomy to repair rhegmatogenous retinal detachments and were followed for 6 months. The presence/absence of RSW was evaluated presurgically on en face optical coherence tomographic images. The internal limiting membrane was peeled if RSW was identified. The main outcome measure was the prevalence of postsurgical epiretinal membrane growth that caused a visual decline of 0.2 or more in logarithm of the minimum angle of resolution unit.
这是一项前瞻性的干预性病例系列，连续 78 只眼睛接受了首次玻璃体切除术以修复孔源性视网膜脱离，并随访了6个月。术前在正面光学相干断层扫描图像上评估RSW的存在/不存在。如果识别出 RSW，则剥离内界膜。主要观察指标是术后视网膜前膜生长的患病率，其导致最小分辨角单位对数视力下降0.2或以上。
Results：The internal limiting membrane was peeled for RSW appearance in 22 eyes (28.2%). Mild epiretinal membranes developed in 8 of the 56 internal limiting membrane–unpeeled eyes (10.3% of total, 6 eyes at stage 1 in the classification of Govetto); however, visual decline occurred in none of them with the mean visual acuity of these 8 eyes maintained at −0.08 ± 0.11 in logarithm of the minimum angle of resolution (≈20/16).
22眼（28.2%）内界膜剥离后出现RSW。56只内界膜未剥的眼睛中有8只出现轻度视网膜前膜（占总数的10.3%，Govetto分类第1阶段有6只眼睛）；然而，这8只眼睛的平均视力保持在-0.08±0.11的最小分辨率角对数（≈20/16），均未出现视力下降。
Conclusion：Visual decline due to epiretinal membrane growth after rhegmatogenous retinal detachment repair was entirely prevented by peeling the internal limiting membrane in about 30% of cases selected for the presence of RSW.
Visual decline due to epiretinal membrane growth after retinal detachment repair was entirely prevented by peeling the internal limiting membrane during the initial vitrectomy in about 30% of eyes selected based on the presence of retinal surface wrinkling.在选择存在 RSW 的约 30% 的病例中，通过剥离内界膜完全防止了由于孔源性视网膜脱离修复后视网膜前膜生长引起的视力下降。

通过在初始玻璃体切除术期间剥离内界膜，完全防止了由于视网膜脱离修复后视网膜前膜生长引起的视力下降，大约 30% 的眼睛根据视网膜表面皱褶的存在而选择。

推荐理由：
ERM 的术后发展是RRD玻璃体切除术后的问题之一，可能会导致术后视力受损和变形。该研究通过在初始玻璃体切除术期间剥离内界膜，完全防止了由于视网膜脱离修复后视网膜前膜生长引起的视力下降。该研究的创新之处在于开展了此次前瞻性研究，以评估视网膜表面皱纹作为RRD修复玻璃体切除术期间ILM剥离的指征有效性，结果表明大约30%的眼睛根据视网膜表面皱褶的存在而选择，均未出现由于视网膜脱离修复后视网膜前膜生长引起的视力下降。

不足之处在于目前只有六个月的随访数据，还需继续进一步监测，以观察其长期有效性。

No.2
Investigative Ophthalmology & Visual Science · 推荐
Choroidal and Retinal Thickness and Axial Eye Elongation in Chinese Junior Students(Invest Ophthalmol Vis Sci. 2021;62(9):26.）

中国低年级学生脉络膜和视网膜厚度及眼轴伸长
Purpose：To explore the associations between macular choroidal and retinal thickness and axial elongation in non-myopic and myopic junior students.
探讨非近视和近视初中生黄斑脉络膜和视网膜厚度与眼轴伸长之间的关系。
Methods：In this school-based longitudinal observational study, axial length was measured by optical low-coherence reflectometry, and choroidal thickness and retinal thickness were measured by spectral-domain optical coherence tomography. Myopia was defined as non-cycloplegic objective spherical equivalent refraction ≤ −0.50 diopters. Structural equation modeling and multiple linear regression models were used to analyze the associations between baseline choroidal and retinal thickness with axial elongation.
在这项以学校为基础的纵向观察研究中，轴长通过光学低相干反射计测量，脉络膜厚度和视网膜厚度通过光谱域光学相干断层扫描测量。近视被定义为非散瞳物镜等效球面屈光度≤ -0.50 屈光度。结构方程模型和多元线性回归模型用于分析基线脉络膜和视网膜厚度与轴向伸长之间的关联。
Results：Out of 1307 students examined at baseline in 2017, 1197 (91.58%) returned for follow-up examination in 2018, with a median age of 12.00 years (interquartile range [IQR], 1.00) and included 667 boys (55.72%). Within a 1-year period, the median axial elongation of right eyes was 230 µm (IQR, 180) in boys and 200 µm (IQR, 160) in girls (P = 0.032). The thinner temporal choroidal thickness was associated with greater 1-year axial elongation only in myopic students (β, −0.20; 95% confidence interval [CI], −0.37, −0.03), the thinner temporal retinal thickness was associated with greater 1-year axial elongation in both non-myopic (β, −2.67; 95% CI, −4.52, −0.82) and myopic (β, −0.99; 95% CI, −1.68, −0.30) students, after adjustment for sex, age, and height. Subfoveal and nasal choroidal and retinal thickness were not significantly associated with axial elongation in either non-myopic or myopic students.
在 2017 年基线检查的 1307 名学生中，1197 名 (91.58%) 于 2018 年返回进行后续检查，中位年龄为 12.00 岁（四分位距 [IQR]，1.00），其中包括 667 名男孩（55.72%） .在 1 年内，男孩右眼的中位轴向伸长为 230 µm（IQR，180），女孩为 200 µm（IQR，160）（P= 0.032）。仅在近视学生中，较薄的颞部脉络膜厚度与较大的 1 年轴向伸长相关（β，-0.20；95% 置信区间 [CI]，-0.37，-0.03），较薄的颞部视网膜厚度与较大的 1-在调整性别、年龄后，非近视（β，-2.67；95% CI，-4.52，-0.82）和近视（β，-0.99；95% CI，-1.68，-0.30）学生的年轴向伸长率, 和高度。中心凹下和鼻部脉络膜和视网膜厚度与非近视或近视学生的轴向伸长没有显着相关性。
Conclusion：A thinner temporal choroid at age 12 years may predict greater 1-year axial elongation in myopic students, and a thinner temporal retina may predict greater 1-year axial elongation in both non-myopic and myopic students. This finding may help to identify children at risk and control axial elongation with potential preventive strategies.
在 12 岁时更薄的颞叶脉络膜可以预测近视学生更大的 1 年轴向伸长，而更薄的颞叶视网膜可以预测非近视和近视学生更大的 1 年轴向伸长。这一发现可能有助于识别有风险的儿童并通过潜在的预防策略控制轴向伸长。
推荐理由
本研究探讨了非近视和近视初中生黄斑脉络膜和视网膜厚度与眼轴伸长之间的关系。结果表明在12岁时更薄的颞叶脉络膜可以预测近视学生更大的 1 年轴向伸长，而更薄的颞叶视网膜可以预测非近视和近视学生更大的 1 年轴向伸长。创新之处在于认识到更薄的颞叶脉络膜和视网膜厚度是轴向伸长的预测因素，可以更早地识别有风险的儿童，以及谁将从潜在的预防策略中受益。

不足之处在于仅观察到了脉络膜和视网膜厚度与轴向延长之间的一年的关联，未来可进行更长时间的随访。

No.3
Ophthalmology · 推荐
Retinal Detachment after Treatment of Retinopathy of Prematurity with Laser versus Intravitreal Anti–Vascular Endothelial Growth Factor(Ophthalmology. 2021;128(8):1188-1196.）

激光与玻璃体内抗血管内皮生长因子治疗早产儿视网膜病变后的视网膜脱离
Purpose：To compare rates of short-term retinal detachment (RD) of infants treated for type 1 retinopathy of prematurity (ROP) with intravitreal anti–vascular endothelial growth factor (VEGF) therapy with infants treated with laser therapy. The choice between these 2 treatments remains controversial. Comparative data are limited and describe re-treatment rates rather than retinal structural outcomes predictive of long-term vision. Anti–vascular endothelial growth factor acts faster than laser therapy, which may be beneficial for more aggressive ROP.
比较接受玻璃体内抗血管内皮生长因子 (VEGF) 治疗的1 型早产儿视网膜病变(ROP ) 的婴儿的短期视网膜脱离(RD) 的发生率与接受激光治疗的婴儿的发生率。这两种治疗方法之间的选择仍然存在争议。比较数据是有限的，描述的是再治疗率，而不是预测长期视力的视网膜结构结果。抗血管内皮生长因子的作用比激光疗法更快，这可能有利于更具侵袭性的 ROP。
Design：Nonrandomized, comparative cohort study.
非随机、比较队列研究。
Participants：The study included 1167 eyes of 640 infants treated for type 1 ROP. Among these, 164 eyes received anti-VEGF therapy and 1003 eyes received laser therapy.
该研究包括 640 名接受 1 型 ROP 治疗的婴儿的 1167 只眼睛。其中抗VEGF治疗164眼，激光治疗1003眼。
Methods：Pretreatment and posttreatment examinations and treatments were completed by ophthalmologists with expertise in ROP. The study was a secondary analysis of data from the retrospective Postnatal Growth and Retinopathy of Prematurity Study (G-ROP) 1 study (2006–2012) and the prospective G-ROP 2 study (2015–2017).
治疗前和治疗后的检查和治疗由具有 ROP 专业知识的眼科医生完成。该研究是对早产儿回顾性出生后生长和视网膜病变研究 (G-ROP) 1 研究（2006-2012 年）和前瞻性 G-ROP 2 研究（2015-2017 年）数据的二次分析。
Main Outcome Measures：Rate of RD (ROP stages 4A, 4B, or 5) within 8 weeks of initial treatment, an end point predictive of poor long-term vision. The results were stratified by postmenstrual age (PMA) at treatment as occurring before versus at or after 36 weeks and 0 days, because earlier disease may be considered more aggressive.
初始治疗 8 周内的 RD 率（ROP 4A、4B 或 5 期），这是预测长期视力不佳的终点。结果根据治疗时的经后年龄 (PMA) 进行分层，分别是发生在 36 周零 0 天之前与之后或之后，因为较早的疾病可能被认为更具侵袭性。
Results：Among 458 eyes treated before PMA 36 weeks and 0 days, the short-term RD rate was higher after laser therapy (29/368 eyes [7.9%]) than after anti-VEGF therapy (0/90 eyes [0%]; P < 0.001). Of 709 eyes treated at or after PMA 36 weeks and 0 days, short-term RD risk did not differ between groups (laser [20/635 eyes], 3.1%; anti-VEGF [1/74 eyes], 1.4%; P = 0.27).
PMA前36周0天治疗的458眼中，激光治疗后短期RD率（29/368眼[7.9%]）高于抗VEGF治疗后（0/90眼[0%]；P < 0.001)。在 PMA 36 周和 0 天时或之后治疗的 709 只眼中，组间短期 RD 风险没有差异（激光 [20/635 眼]，3.1%；抗 VEGF [1/74 眼]，1.4%；P = 0.27）。
Conclusion：Anti–vascular endothelial growth factor therapy results in better short-term structural outcomes than laser therapy when type 1 ROP is treated before 36 weeks’ PMA. After this age, both treatments have very low rates of short-term RD. The faster action of anti-VEGF agents likely is responsible for these findings.
在 PMA 前 36 周治疗 1 型 ROP 时，抗血管内皮生长因子治疗的短期结构性结果优于激光治疗。在这个年龄之后，两种治疗的短期 RD 率都非常低。抗 VEGF 药物的更快作用可能是造成这些发现的原因。
推荐理由
研究中，大量治疗的眼睛能够比较激光治疗和抗 VEGF 治疗在治疗时按 PMA 分层。许多医院和许多不同的主治医生的地理和种族多样化样本提高了研究结果的普遍性。文章的创新之处在于证实了在 PMA 前 36 周 0 天，抗 VEGF 治疗比激光治疗具有明显的短期结构性益处，并表明在 1 型诊断时更客观的 PMA 测量可能优于对疾病区域的主观判断。然而，这种益处必须与其他风险和益处一起考虑，包括长期结构性结果、长期视力结果以及接受抗 VEGF 药物治疗的患者的短期和长期安全性数据。

不足之处在于尽管该研究中接受治疗的眼睛总数很大，但某些亚组中接受抗 VEGF 药物治疗的眼睛数量，例如 36 周 PMA 时或之后的治疗，可能限制了检测组间差异的能力。

三篇论文原文已放在百度网盘中，点击“链接”，输入提取码：fcvb ，即可下载原文。
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重磅！卫视博与珠海亿胜达成战略合作

8月5日，广州卫视博与珠海亿胜召开销售合作线上会议。广州卫视博董事长＆总经理高前应及市场团队，珠海亿胜生物制药有限公司副总裁＆珠海亿胜医药有限公司总裁陈培胜、珠海亿胜生物制药有限公司市场总监＆珠海亿胜医药有限公司副总裁李海才及其市场团队参加此次会议。因疫情原因，本次会议采取线上进行，将近30位销售精英在相互了解中畅所欲言，共谋发展新篇章！

会议伊始，亿胜陈培胜总裁和卫视博高前应总经理先后发表致辞。陈总首先对双方的合作表示感谢，简要介绍亿胜销售团队情况，基于亿胜在眼科产品销售上积累的经验和卫视博全球创新的眼科产品，希望在双方共同努力下，达成更深入的战略合作。高总对珠海亿胜选择卫视博的合作表示感谢，他进一步表示，折叠式人工玻璃体球囊是全球独创产品，推广极具挑战性，希望双方相互学习交流，充分了解产品特点，坚定信心，密切合作，共同为患者服务。此外，卫视博后续会陆续推出另外二个创新产品：折叠顶压球囊和高度近视后巩膜加固系统，未来合作空间充足，期待与亿胜携手并进，长期合作，共赢未来。

 

随后，双方团队相互介绍，并针对合作区域市场情况做初步介绍，卫视博将给予珠海亿胜在全国部分区域的FCVB代理权。大家在愉快的交流中，对彼此公司、团队及发展理念有了初步认识，同时，加强了双方的合作信任，对稳定和扩大FCVB产品市场和品牌影响力起到了积极的作用。待新冠疫情缓解后，双方将针对每个区域推广进行面对面更深入交流。

通过本次会议，卫视博与亿胜彼此共赢、共发展的合作理念更加清晰。未来，卫视博将与珠海亿胜携手并进，共同开拓眼科植入产品市场，将有意义的眼科创新产品更好地推向市场，服务患者，共赢未来。卫视博也将以更加开放的心态向经销商合作伙伴提供更广阔的发展空间，创造更多更好的合作机会！

合作公司：珠海亿胜

珠海亿胜生物制药有限公司是由亿胜生物制药有限公司(香港)投资控股的外商独资企业，主要从事基因工程药物的研究、开发、生产和销售。

公司于1996年6月10日注册成立，总投资额5000万元人民币，拥有符合GMP规范的生产厂房、开发研究中心、质检中心及营销中心。目前已成功开发出两个国家一类基因工程新药及系列生物药物，公司主要产品为:贝复济、贝复舒、贝复新。贝复济和贝复舒的研制成功，使公司在创伤修复药物研究和生产领域跨入世界先进行列。

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7月 | Vesber 最佳RIO论文推荐

卫视博每月从三大权威杂志：Retina、Investigative Ophthalmology & Visual Science、Ophthalmology中各推荐一篇眼科论文。— — 最佳“RIO”论文推荐（7月）
No.1  Retina · 推荐

Prevalence of vitreous cortex remnants in eyes with primary rhegmatogenous retinal detachment undergoing vitrectomy

(Retina. 2021;41(7)_1403-1406.）

原发性孔源性视网膜脱离患者玻璃体切除术后玻璃体皮质残留的发生率

Purpose：To evaluate the prevalence and extent of vitreous cortex remnants (VCR) on the surface of the retina in eyes with primary rhegmatogenous retinal detachment (RRD) and posterior vitreous detachment.

探讨原发性孔源性视网膜脱离（RRD）和玻璃体后脱离患者视网膜表面玻璃体皮质残留（VCR）的发生率及程度。

Materials and Methods：Triamcinolone acetonide was injected in the vitreous cavity of 100 consecutive cases of acute primary RRD undergoing pars plana vitrectomy. A multivariate regression analysis was performed to determine any association between the presence and pattern of stained VCR on the surface of the retina and the following variables: age, diabetes, axial length (AL), phakic status, extent of RRD and macular status.

对100例急性原发性RRD行玻璃体平坦部切除术的患者行玻璃体腔注射曲安奈德。进行多元回归分析，以确定视网膜表面染色模式存在下的玻璃体皮质残留与年龄、糖尿病、轴长（AL）、晶状体状态、RRD程度和黄斑状态等变量之间的关系。

Results：VCR were found in 42 eyes. These were focal in 8 eyes and diffuse in 34 eyes. Age was the only strong and independent risk factor associated with the presence of VCR (p=0.0019). Age (p<0.0001), AL (p=0.0037) and phakia (p=0.01) were independent risk factors associated with the diffuse pattern. Neither diabetes, extent of RRD nor macular status were significant risk factors for the presence or extent of VCR.

42只眼发现玻璃体皮质残留。病灶8眼，弥漫34眼。年龄是唯一与玻璃体皮质残留相关的独立危险因素（p=0.0019）。年龄（p<0.0001）、AL（p=0.0037）和晶状体混浊（p=0.01）是与弥散型相关的独立危险因素。糖尿病、RRD程度和黄斑状态均不是玻璃体皮质残留存在及严重程度的重要危险因素。

Conclusion：Older patients with primary RRD and PVD appear to be at a higher risk of having diffuse VCR. Further studies are needed to investigate the relevance of VCR in the pathogenesis, progression and treatment of RD.

患有原发性RRD和玻璃体后脱离的老年患者出现弥漫性玻璃体皮质残留的风险较高。玻璃体皮质残留在视网膜脱离的发病机制、进展和治疗中的相关性尚需进一步研究。

推荐理由：本文研究了原发性孔源性视网膜脱离与玻璃体后脱离患者行玻璃体切除术后发生玻璃体皮质残留的风险因素，得出年龄是出现弥漫性玻璃体皮质残留的重要风险因素。

本文创新之处在于通过染色，有效的观察了玻璃体皮质残留的情况，并对应相关的变量因素进行了统计分析，得出了玻璃体皮质残留与年龄具有相关性，暗示高龄患者需更加关注术后的反应。

文章不足之处在于文章证明了玻璃体皮质残留与视网膜脱离具有相关性，但是具体的相关因素仍有待进一步探讨，未来需增加对照。

No.2  Investigative Ophthalmology & Visual Science · 推荐

Association of Aberrant Posterior Vitreous Detachment and Pathologic Tractional Forces With Myopic Macular Degeneration

( Invest Ophthalmol Vis Sci. 2021;62(7)_7.）

异常玻璃体后脱离和病理牵引力与近视黄斑变性的关系

Purpose：The purpose of this study was to assess whether the tractional elements of pathologic myopia (PM; e.g. myopic traction maculopathy [MTM], posterior staphyloma[PS], and aberrant posterior vitreous detachment [PVD]) are associated with myopic macular degeneration (MMD) independent of age and axial length, among highly myopic (HM) eyes.

本研究的目的是评估病理性近视的牵引因素（如：近视牵引性黄斑病变[MTM]、后葡萄肿[PS]和异常后玻璃体脱离[PVD]）是否与高度近视（HM）眼的近视性黄斑变性（MMD）相关，而与年龄和眼轴长度无关。

Methods：One hundred twenty-nine individuals with 239 HM eyes from the Myopic and Pathologic Eyes in Singapore (MyoPES) cohort underwent ocular biometry, fundus photography, swept-source optical coherence tomography, and ocular B-scan ultrasound.Images were analyzed for PVD grade, and presence of MTM, PS, and MMD. The χ2 test was done to determine the difference in prevalence of MMD between eyes with and without PVD, PS, and MTM. Multivariate probit regression analyses were performed to ascertain the relationship between the potential predictors (PVD, PS, and MTM) and outcome variable (MMD), after accounting for possible confounders (e.g. age and axial length). Marginal effects were reported.

对来自新加坡近视眼和病理眼（MyoPES）队列的129例239只高度近视眼患者进行了眼部生物测量、眼底照相、扫描源光学相干断层扫描和眼部B超检查。分析异常后玻璃体脱离级别、近视牵引性黄斑病变、后葡萄肿和近视性黄斑变性的存在。用χ2检验分析异常后玻璃体脱离、后葡萄肿、近视牵引性黄斑病变眼近视性黄斑变性患病率是否存在差异。在排除可能存在的混杂因素（如年龄和轴向长度）后，进行多变量线性回归分析以确定潜在预测因素（异常后玻璃体脱离、后葡萄肿和近视牵引性黄斑病变）与结果变量（近视性黄斑变性）之间的关系。报道边缘效应。

Results：Controlling for potential confounders, eyes with MTM have a 29.92 percentage point higher likelihood of having MMD (P = 0.003), and eyes with PS have a 25.72 percentage point higher likelihood of having MMD (P = 0.002). The likelihood of MMD increases by 10.61 percentage points per 1 mm increase in axial length (P < 0.001). Subanalysis revealed that eyes with incomplete PVD have a 22.54 percentage point higher likelihood of having MMD than eyes with early PVD (P = 0.04).

控制潜在的混杂因素后，近视牵引性黄斑病变患者患近视性黄斑变性的可能性高29.92个百分点（P=0.003），后葡萄肿患者患近视性黄斑变性的可能性高25.72个百分点（P=0.002）。轴向长度每增加1mm，发生近视性黄斑变性的可能性增加10.61个百分点（P<0.001）。亚组分析显示，不完全性异常后玻璃体脱离眼发生近视性黄斑变性的可能性比早期异常后玻璃体脱离眼高22.54个百分点（P=0.04）。

Conclusion：Our study demonstrated an association between tractional (MTM, PS, and persistently incomplete PVD) and degenerative elements of PM independent of age andaxial length. These data provide further insights into the pathogenesis of MMD.

我们的研究证实了病理性近视的牵引（近视牵引性黄斑病变、后葡萄肿和持续不完全异常后玻璃体脱离）和退行性因素之间的关联，与年龄和轴长无关。这些数据为近视性黄斑变性的发病机制提供了进一步的见解。

推荐理由：本文研究了病理性近视的牵引与近视性黄斑变性的关联，得出黄斑变性与年龄和眼轴长度的关联不大，和病理性近视造成的牵引性关联显著。

文章创新之处在于通过大数据样本量的数据图片分析得出了近视性黄斑变性的发病机制的新的见解。同时通过科学的统计方式，控制了混杂因素，使结果更可靠。

本文的不足之处在于研究的素材均是图片素材，缺乏直接的解刨证据的收集，未来可从其他方面综合侧面分析牵引力的作用，进一步验证分析结果的真实性。

No.3   Ophthalmology · 推荐

THE BIDIRECTIONAL RELATIONSHIP BETWEEN VISION AND COGNITION: A SYSTEMATIC REVIEW AND META-ANALYSIS

(Ophthalmology. 2021;128(7)_981-992.）

视觉与认知的双向关系：系统综述与META分析

Topic：Visual impairment (VI) and cognitive impairment (CIM) are prevalent age-related conditions that impose substantial burden on the society. While the bidirectional association of VI and CIM has been hypothesized, findings have been equivocal. Hence, we conduct a systematic review and meta-analysis to examine the bidirectional relationship between VI and CIM. Clinical Relevance: 60% risk of CIM has not been well-elucidated in the literature. A bidirectional relationship between CIM and VI may provide opportunities for developing public health strategies for early detection and management of risk factors for both VI and CIM in older people.

视力障碍（VI）和认知障碍（CIM）是普遍存在的与年龄相关的疾病，给社会带来了巨大的负担。但是，已有的模棱两可的发现中，视力障碍和认知障碍的双向关联都是假设。因此，我们进行了系统的回顾和meta分析来检验视力障碍和认知障碍之间的双向关系。临床相关性也显示：60%的认知障碍风险在文献中没有很好的阐明。但搞清楚认知障碍和视力障碍之间的双向关系可能为制定公共卫生战略提供机会，以便早期发现和管理老年人中视力障碍和认知障碍的风险因素。

Methods：Pubmed, Embase and Cochrane Central registers were systematically searched for observational studies, published from inception until 6 April 2020, in adults aged ≥ 40 years reporting objectively measured VI, and CIM assessment using clinically validated cognitive screening tests or diagnostic evaluation. Meta-analyses on cross-sectional and longitudinal associations between VI and CIM outcomes (any CIM assessed using screening tests, and clinically diagnosed dementia) were examined. Random effect models were used to generate pooled odds ratios (OR), and 95% confidence interval (CI). Publication bias and heterogeneity were examined using Egger’s test, meta-regression, and trim-and-fill methods.

对Pubmed、Embase和Cochrane中央登记册进行了系统的搜索，使用经临床验证的认知筛查测试或诊断评估方法、对系统从开始到2020年4月6日发表的年龄大于40的老年人的观察性研究中的客观测量视力障碍和认知障碍数据进行评估。对视力障碍和认知障碍结果之间的横截面和纵向关联进行荟萃分析（使用筛选试验评估的任何认知障碍，以及临床诊断的痴呆）。随机效应模型用于产生合并优势比（OR）和95%置信区间（CI）。使用Egger’s测验、元回归和修剪填充法检查发表偏差和异质性。

Results：Forty studies were included (N=47,913,570). Meta-analyses confirmed that persons with VI were more likely to have CIM, with significantly higher odds [OR (95%CI)] of: (i) any CIM [cross-sectional: 2.38 (1.84-3.07); longitudinal: 1.66 (1.46-1.89)], and (ii) clinically diagnosed dementia [(cross-sectional: 2.43 (1.48-4.01); longitudinal: 2.09 (1.37-3.21)], compared to persons without VI. Significant heterogeneity was partially explained by differences in age, sex and follow-up duration. There was also some evidence that individuals with CIM, relative to cognitively intact persons, were more likely to have VI, with most papers (8/9, 89%) reporting significantly positive associations, however meta-analyses on this association could not be conducted due to insufficient data.

共纳入40项研究（N=47913570）。Meta分析证实，视力障碍患者更容易发生认知障碍，其发生认知障碍的几率（OR（95%CI））显著高于无视力障碍的人：比如（i）任何认知障碍[横截面：2.38（1.84-3.07）；纵向：1.66（1.46-1.89）]；和（ii）临床诊断痴呆[横截面：2.43（1.48-4.01）；纵向：2.09（1.37-3.21）]。年龄、性别和随访时间部分解释了统计的异质性。大多数论文（8/9，89%）报告表明，与认知完整的人相比，认知障碍患者更有可能出现视力障碍，但是由于数据不足，无法对这种关联进行荟萃分析。

Conclusion：Overall, our work suggests that VI is a risk factor of CIM while further work is needed to confirm the association of CIM as a risk factor for VI. Strategies for early detection and management of both visual and cognitive impairment in older people may minimize individual clinical and public health consequences.

总的来说，我们的工作表明，视力障碍是认知障碍的一个危险因素，同时需要进一步的工作来确认认知障碍是视力障碍的一个危险因素。早期发现和管理老年人视觉和认知障碍的策略可以最大限度地减少个人的临床和公共健康后果。

推荐理由：本研究探索了视力障碍与认知障碍之间的彼此关系，得出视力障碍是认知障碍的一个高危因素，需重视老年人的视力健康，预防老年视力受损，避免进一步造成认知障碍。

文章创新点是通过大数据的统计与回顾分析，确认了有视力障碍的人员比无视力障碍的人员有更高认知障碍风险，暗示了视力变化是认知障碍的重要关键因素。

文章的不足之处为仅解释了视力障碍是认知障碍的高危因素，但是认知障碍对视力障碍的影响不明，两者的相互关联依旧是不明确的，需做进一步的统计分析研究，比如选取有认知障碍的老年痴呆患者，对比同龄未换老年痴呆的患者的视力进行对比统计分析。

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